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studied measurements of             Table 1: Anthropometric characteristics of the participants
these antibodies (ASCA-IgA,
immunoglobulin A and ASCA-          Participants                    Control group  Obese group
IgG, immunoglobulin G) in
obese contra normal weight          n=58                                  n=18     n=40
individuals in relation to obesity
indices (weight, BMI and waist      Age (years)                      40.4 (±15.5)  45.4 (± 11.0)
circumference) and high sensitive
C-reactive protein (HS-CRP).        Male/Female ratio                     0.6 0.6
This in order to find out possible
relationships between these         Weight (kg)                     68.3 (± 12.5)  128.2 (± 23.4)
antibodies and obesity related
indices as well as low-grade        Waist circumference (cm)         83.5 (± 6.6)  130.5 (± 14.3)
inflammation common in obese
individuals.                        BMI1 (kg/m2)                     23.4 (± 2.3)  43.4 (± 5.3)

Methods                             1 BMI=Body Mass Index (kg/m2).
Forty obese individuals with a
body mass index of, BMI ≥35         linked immunosorbent assay). HS-      (P=0.03). This antibody was
[weight (kg)/height (m2)] and 18    CRP was measured by standard          positively associated with weight
healthy normal weight controls      methods. Written informed             (P=0.01), BMI (P=0.02) and waist
[BMIs of 18-25 (kg/m2)] were        consent was obtained from all         circumference (P=0.02), but not
recruited for this case-control     participants before enrolling in the  with HS-CRP. Age and gender did
study. The obese patients were      study. This study was conducted       not affect ASCA levels. HS-CRP
recruited from the Obesity          according to the guidelines           analysis results were, as expected,
Polyclinic at St. Olav University   laid down in the Declaration of       significantly higher in the obese
Hospital (Trondheim, Norway)        Helsinki and was approved by the      (8.6 mg/l ± 14.1, vs. 0.85 mg/l ±
and the controls were members       regional Ethics Committee (Midt-      0.7, P <0.05) but did not show
of the staff. An overview of the    Norge, Trondheim, Norway; Ref.        any correlation with ASCA, nor
demographics of participants is     2012/1877).                           obesity related indices.
shown in table 1. Binding activity
of serum IgA (immunoglobulin A)     Results and discussion                The prevalence of ASCA titers in
and IgG (immunoglobulin G) to the   More than a third of the obese        our study is comparable to those
cell wall mannan of S. cerevisiae   individuals (35 %) showed             found in several diseases related
was measured by ELIZA (enzyme       positive or elevated titers of        to autoimmune system (6). None
                                    ASCA compared with the control        of our participants had Crohn’s,
                                    group (5 %) figure 2. IgA-ASCA        this disease being an exclusion
                                    levels in obese patients were         factor in this study. It seems these
                                    significantly higher than those       antibodies are not specific for
                                    found in the control group            Crohn’s disease.

1 Center for Obesity and innovation (ObeCe), St. Olav University Hospital, Trondheim Norway
2 Obesity Research group, Department of Cancer Research and molecular medicine, Faculty of medicine, Norwegian University of Science and technology (NTNU),

    Trondheim, Norway

                                                                                   Summer 2016 BAKINGEUROPE
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